List of Publications

Lene Lange, publications 2015-2022 and selected papers 1974-2014

Genome Annotation, Function & Evolution

#1 Barrett, K.; Lange, L. Peptide-Based Functional Annotation of Carbohydrate-Active Enzymes by Conserved Unique Peptide Patterns (CUPP). Biotechnol Biofuels 2019, 12, 102, doi:10.1186/s13068-019-1436-5.

#2 Barrett, K.; Hunt, C.J.; Lange, L.; Meyer, A.S. Conserved Unique Peptide Patterns (CUPP) Online Platform: Peptide-Based Functional Annotation of Carbohydrate Active Enzymes. Nucleic Acids Research 2020, 48, W110–W115, doi:10.1093/nar/gkaa375

#3 Barrett, K.; Jensen, K.; Meyer, A.S.; Frisvad, J.C.; Lange, L. Fungal Secretome Profile Categorization of CAZymes by Function and Family Corresponds to Fungal Phylogeny and Taxonomy: Example Aspergillus and Penicillium. Sci Rep 2020, 10, 5158, doi:10.1038/s41598-020-61907-1.

#4 Lange, L.; Barrett, K.; Meyer, A.S. New Method for Identifying Fungal Kingdom Enzyme Hotspots from Genome Sequences. JoF 2021, 7, 207, doi:10.3390/jof7030207.

#5 Lange, L.; Grell, M.N. The Prominent Role of Fungi and Fungal Enzymes in the Ant–Fungus Biomass Conversion Symbiosis. Appl Microbiol Biotechnol 2014, 98, 4839–4851, doi:10.1007/s00253-014-5708-5.

#6 Busk, P.K.; Lange, L. Function-Based Classification of Carbohydrate-Active Enzymes by Recognition of Short, Conserved Peptide Motifs. Appl Environ Microbiol 2013, 79, 3380–3391, doi:10.1128/AEM.03803-12.

#7 Schiøtt, M.; De Fine Licht, H.H.; Lange, L.; Boomsma, J.J. Towards a Molecular Understanding of Symbiont Function: Identification of a Fungal Gene for the Degradation of Xylan in the Fungus Gardens of Leaf-Cutting Ants. BMC Microbiol 2008, 8, 40, doi:10.1186/1471-2180-8-40.

#8 Lydolph, M.C.; Jacobsen, J.; Arctander, P.; Gilbert, M.T.P.; Gilichinsky, D.A.; Hansen, A.J.; Willerslev, E.; Lange, L. Beringian Paleoecology Inferred from Permafrost-Preserved Fungal DNA. Appl Environ Microbiol 2005, 71, 1012–1017, doi:10.1128/AEM.71.2.1012-1017.2005.

Lange, L.; Pilgaard, B.; Herbst, F.-A.; Busk, P.K.; Gleason, F.; Pedersen, A.G. Origin of Fungal Biomass Degrading Enzymes: Evolution, Diversity and Function of Enzymes of Early Lineage Fungi. Fungal Biology Reviews 2019, 33, 82–97, doi:10.1016/j.fbr.2018.09.001.

Lange, L.; Barrett, K.; Pilgaard, B.; Gleason, F.; Tsang, A. Enzymes of Early-Diverging, Zoosporic Fungi. Appl Microbiol Biotechnol 2019, 103, 6885–6902, doi:10.1007/s00253-019-09983-w.

Hu, H.; da Costa, R.R.; Pilgaard, B.; Schiøtt, M.; Lange, L.; Poulsen, M. Fungiculture in Termites Is Associated with a Mycolytic Gut Bacterial Community. mSphere 2019, 4, e00165-19, doi:10.1128/mSphere.00165-19.

Gleason, F.H.; Pilgaard, B.; Henderson, L.; Lange, L. The Key Ecological Role and Biology of Rhizophlyctis Rosea, a Zoosporic, Early Lineage Fungus in Soil Ecosystems. Current Trends in Microbiology 2019, 60, 67–80, doi:http://researchtrends.net/tia/abstract.asp.

Gleason, F.H.; Lilje, O.; Lange, L. What Has Happened to the “Aquatic Phycomycetes” (Sensu Sparrow)? Part II: Shared Properties of Zoosporic True Fungi and Fungus-like Microorganisms. Fungal Biology Reviews 2018, 32, 52–61, doi:10.1016/j.fbr.2017.09.003.

da Costa, R.R.; Hu, H.; Pilgaard, B.; Vreeburg, S.M.E.; Schückel, J.; Pedersen, K.S.K.; Kračun, S.K.; Busk, P.K.; Harholt, J.; Sapountzis, P.; et al. Enzyme Activities at Different Stages of Plant Biomass Decomposition in Three Species of Fungus-Growing Termites. Appl Environ Microbiol 2018, 84, e01815-17, doi:10.1128/AEM.01815-17.

Busk, P.K.; Pilgaard, B.; Lezyk, M.J.; Meyer, A.S.; Lange, L. Homology to Peptide Pattern for Annotation of Carbohydrate-Active Enzymes and Prediction of Function. BMC Bioinformatics 2017, 18, 214, doi:10.1186/s12859-017-1625-9.

Małagocka, J.; Grell, M.N.; Lange, L.; Eilenberg, J.; Jensen, A.B. Transcriptome of an Entomophthoralean Fungus (Pandora Formicae) Shows Molecular Machinery Adjusted for Successful Host Exploitation and Transmission. Journal of Invertebrate Pathology 2015, 128, 47–56, doi:10.1016/j.jip.2015.05.001.

Grell, M.N.; Linde, T.; Nygaard, S.; Nielsen, K.L.; Boomsma, J.J.; Lange, L. The Fungal Symbiont of Acromyrmex Leaf-Cutting Ants Expresses the Full Spectrum of Genes to Degrade Cellulose and Other Plant Cell Wall Polysaccharides. BMC Genomics 2013, 14, 928, doi:10.1186/1471-2164-14-928

Enzyme Discovery

Tan, M.H.; Loke, S.; Croft, L.J.; Gleason, F.H.; Lange, L.; Pilgaard, B.; Trevathan-Tackett, S.M. First Genome of Labyrinthula sp., an Opportunistic Seagrass Pathogen, Reveals Novel Insight into Marine Protist Phylogeny, Ecology and CAZyme Cell-Wall Degradation. Microb Ecol 2021, 82, 498–511, doi:10.1007/s00248-020-01647-x. (L. sp. -non-fungal, fungal-like)

Kang, D.; Huang, Y.; Nesme, J.; Herschend, J.; Jacquiod, S.; Kot, W.; Hansen, L.H.; Lange, L.; Sørensen, S.J. Metagenomic Analysis of a Keratin-Degrading Bacterial Consortium Provides Insight into the Keratinolytic Mechanisms. Science of The Total Environment 2021, 761, 143281, doi:10.1016/j.scitotenv.2020.143281.

Ji, X.; Xue, Y.; Li, Z.; Liu, Y.; Liu, L.; Busk, P.K.; Lange, L.; Huang, Y.; Zhang, S. Ionozyme: Ionic Liquids as Solvent and Stabilizer for Efficient Bioactivation of CO2. Green Chem. 2021, 23, 6990–7000, doi:10.1039/D1GC02503A.

Espersen, R.; Huang, Y.; Falco, F.C.; Hägglund, P.; Gernaey, K.V.; Lange, L.; Svensson, B. Exceptionally Rich Keratinolytic Enzyme Profile Found in the Rare Actinomycetes Amycolatopsis Keratiniphila D2T. Appl Microbiol Biotechnol 2021, 105, 8129–8138, doi:10.1007/s00253-021-11579-2.

Xue, Y.; Zhao, Y.; Ji, X.; Yao, J.; Busk, P.K.; Lange, L.; Huang, Y.; Zhang, S. Advances in Bio-Nylon 5X: Discovery of New Lysine Decarboxylases for the High-Level Production of Cadaverine. Green Chem. 2020, 22, 8656–8668, doi:10.1039/D0GC03100C.

Lange, L.; Busk, P.K. Glycoside Hydrolases from Thermophlic Fungi 2020. https://patents.google.com/patent/US10647971B2/en?oq=US+10%2c647%2c971+B2

Gilchrist, C.L.M.; Lacey, H.J.; Vuong, D.; Pitt, J.I.; Lange, L.; Lacey, E.; Pilgaard, B.; Chooi, Y.-H.; Piggott, A.M. Comprehensive Chemotaxonomic and Genomic Profiling of a Biosynthetically Talented Australian Fungus, Aspergillus Burnettii Sp. Nov. Fungal Genetics and Biology 2020, 143, 103435, doi:10.1016/j.fgb.2020.103435

Pilgaard, B.; Wilkens, C.; Herbst, F.-A.; Vuillemin, M.; Rhein-Knudsen, N.; Meyer, A.S.; Lange, L. Proteomic Enzyme Analysis of the Marine Fungus Paradendryphiella Salina Reveals Alginate Lyase as a Minimal Adaptation Strategy for Brown Algae Degradation. Sci Rep 2019, 9, 12338, doi:10.1038/s41598-019-48823-9.

Nielsen, C.F.; Lange, L.; Meyer, A.S. Classification and Enzyme Kinetics of Formate Dehydrogenases for Biomanufacturing via CO2 Utilization. Biotechnology Advances 2019, 37, 107408, doi:10.1016/j.biotechadv.2019.06.007.

Huang, Y.; Zheng, X.; Pilgaard, B.; Holck, J.; Muschiol, J.; Li, S.; Lange, L. Identification and Characterization of GH11 Xylanase and GH43 Xylosidase from the Chytridiomycetous Fungus, Rhizophlyctis Rosea. Appl Microbiol Biotechnol 2019, 103, 777–791, doi:10.1007/s00253-018-9431-5

Holck, J.; Fredslund, F.; Møller, M.S.; Brask, J.; Krogh, K.B.R.M.; Lange, L.; Welner, D.H.; Svensson, B.; Meyer, A.S.; Wilkens, C. A Carbohydrate-Binding Family 48 Module Enables Feruloyl Esterase Action on Polymeric Arabinoxylan. Journal of Biological Chemistry 2019, 294, 17339–17353, doi:10.1074/jbc.RA119.009523.

Holck, J.; Djajadi, D.T.; Brask, J.; Pilgaard, B.; Krogh, K.B.R.M.; Meyer, A.S.; Lange, L.; Wilkens, C. Novel Xylanolytic Triple Domain Enzyme Targeted at Feruloylated Arabinoxylan Degradation. Enzyme and Microbial Technology 2019, 129, 109353, doi:10.1016/j.enzmictec.2019.05.010.

Godoy, A.S.; Pereira, C.S.; Ramia, M.P.; Silveira, R.L.; Camilo, C.M.; Kadowaki, M.A.; Lange, L.; Busk, P.K.; Nascimento, A.S.; Skaf, M.S.; et al. Structure, Computational and Biochemical Analysis of PcCel45A Endoglucanase from Phanerochaete Chrysosporium and Catalytic Mechanisms of GH45 Subfamily C Members. Sci Rep 2018, 8, 3678, doi:10.1038/s41598-018-21798-9.

Bentil, J.A.; Thygesen, A.; Mensah, M.; Lange, L.; Meyer, A.S. Cellulase Production by White-Rot Basidiomycetous Fungi: Solid-State versus Submerged Cultivation. Appl Microbiol Biotechnol 2018, 102, 5827–5839, doi:10.1007/s00253-018-9072-8.

Pitt, J.I.; Lange, L.; Lacey, A.E.; Vuong, D.; Midgley, D.J.; Greenfield, P.; Bradbury, M.I.; Lacey, E.; Busk, P.K.; Pilgaard, B.; et al. Aspergillus Hancockii Sp. Nov., a Biosynthetically Talented Fungus Endemic to Southeastern Australian Soils. PLoS ONE 2017, 12, e0170254, doi:10.1371/journal.pone.0170254

Busk, P.K.; Lange, L. Hitherto Unknown Glycoside Hydrolases from Thermophilic Fungi 2017. https://patents.google.com/patent/DK2668265T3/

Lange, L.; Parmar, V.; Meyer, A. Biocatalysis. In Encyclopedia of Sustainable Technologies; Abraham, M.A., Ed.; Elsevier: Oxford, 2017; pp. 663–673 ISBN 978-0-12-804792-7, doi:10.1016/B978-0-12-409548-9.10254-4

Tong, X.; Busk, P.K.; Lange, L.; Pang, J. New Insights into the Molecular Mechanism of Methanol-Induced Inactivation of Thermomyces Lanuginosus Lipase: A Molecular Dynamics Simulation Study. Molecular Simulation 2016, 42, 434–445, doi:10.1080/08927022.2015.1059938.

Tong, X.; Busk, P.K.; Lange, L. Characterization of a New Sn-1,3-Regioselective Triacylglycerol Lipase from Malbranchea Cinnamomea. Biotechnology and Applied Biochemistry 2016, 63, 471–478, doi:10.1002/bab.1394.

Lange, L.; Wu, W.; Aubert, D.; Landvik, S.; Clausen, I.G. Polypeptides Having Cellobiohydrolase I Activity and Polynucleotides Encoding Same 2016. https://patents.google.com/patent/US9447399B2/en?oq=US+9.447%2c399B2

Lange, L.; Huang, Y.; Busk, P.K. Microbial Decomposition of Keratin in Nature—a New Hypothesis of Industrial Relevance. Appl Microbiol Biotechnol 2016, 100, 2083–2096, doi:10.1007/s00253-015-7262-1.

Lange, L.; Busk, P.K. Glycoside Hydrolases from Thermophilic Fungi 2016. https://patents.google.com/patent/US9353363B2/en?oq=US+9%2c353%2c363B2

Huang, Y.; Willats, W.G.; Lange, L.; Jin, Y.; Fang, Y.; Salmeán, A.A.; Pedersen, H.L.; Busk, P.K.; Zhao, H. High-Throughput Microarray Mapping of Cell Wall Polymers in Roots and Tubers during the Viscosity-Reducing Process: CoMPP for Cell Wall Polymers in Roots and Tubers. Biotechnology and Applied Biochemistry 2016, 63, 178–189, doi:10.1002/bab.1367.

Dotsenko, G.; Tong, X.; Pilgaard, B.; Busk, P.K.; Lange, L. Acidic–Alkaline Ferulic Acid Esterase from Chaetomium Thermophilum Var. Dissitum: Molecular Cloning and Characterization of Recombinant Enzyme Expressed in Pichia Pastoris. Biocatalysis and Agricultural Biotechnology 2016, 5, 48–55, doi:10.1016/j.bcab.2015.12.001.

Dotsenko, G.; Nielsen, M.K.; Lange, L. Statistical Model Semiquantitatively Approximates Arabinoxylooligosaccharides’ Structural Diversity. Carbohydrate Research 2016, 426, 9–14, doi:10.1016/j.carres.2016.03.009.

Tong, X.; Lange, L.; Grell, M.N.; Busk, P.K. Hydrolysis of Wheat Arabinoxylan by Two Acetyl Xylan Esterases from Chaetomium Thermophilum. Appl Biochem Biotechnol 2015, 175, 1139–1152, doi:10.1007/s12010-014-1348-6.

Lange, L.; Wu, W.; Aubert, D.; Landvik, S.; Schnorr, K.M.; Clausen, I.G. Polypeptides Having Cellobiohydrolase I Activity and Polynucleotides Encoding Same 2015. https://patents.google.com/patent/US9187739B2/en?oq=US+9%2c187%2c739B2

Lange, L.; Busk, P.; Yuhong, H. Composition and Method for Degradation of Keratinaceous Materials 2015. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015158719

Huang, Y.; Busk, P.K.; Lange, L. Cellulose and Hemicellulose-Degrading Enzymes in Fusarium Commune Transcriptome and Functional Characterization of Three Identified Xylanases. Enzyme and Microbial Technology 2015, 73–74, 9–19, doi:10.1016/j.enzmictec.2015.03.001.

Huang, Y.; Busk, P.K.; Herbst, F.-A.; Lange, L. Genome and Secretome Analyses Provide Insights into Keratin Decomposition by Novel Proteases from the Non-Pathogenic Fungus Onygena Corvina. Appl Microbiol Biotechnol 2015, 99, 9635–9649, doi:10.1007/s00253-015-6805-9.

Busk, P.K.; Lange, L. Classification of Fungal and Bacterial Lytic Polysaccharide Monooxygenases. BMC Genomics 2015, 16, 368, doi:10.1186/s12864-015-1601-6.

Bech, L.; Herbst, F.-A. On-Site Enzyme Production by Trichoderma Asperellum for the Degradation of Duckweed. Fungal Genom Biol 2015, 05, doi:10.4172/2165-8056.1000126.

Huang, Y.; Busk, P.K.; Grell, M.N.; Zhao, H.; Lange, L. Identification of a β-Glucosidase from the Mucor Circinelloides Genome by Peptide Pattern Recognition. Enzyme and Microbial Technology 2014, 67, 47–52, doi:10.1016/j.enzmictec.2014.09.002.

Busk, P.K.; Lange, M.; Pilgaard, B.; Lange, L. Several Genes Encoding Enzymes with the Same Activity Are Necessary for Aerobic Fungal Degradation of Cellulose in Nature. PLoS ONE 2014, 9, e114138, doi:10.1371/journal.pone.0114138.

Bech, L.; Busk, P.K.; Lange, L. Cell Wall Degrading Enzymes in Trichoderma Asperellum Grown on Wheat Bran. Fungal Genom Biol 2014, 04, doi:10.4172/2165-8056.1000116.

Busk, P.; Lange, L. Cellulolytic Potential of Thermophilic Species from Four Fungal Orders. AMB Express 2013, 3, 47, doi:10.1186/2191-0855-3-47.

Rineau, F.; Roth, D.; Shah, F.; Smits, M.; Johansson, T.; Canbäck, B.; Olsen, P.B.; Persson, P.; Grell, M.N.; Lindquist, E.; et al. The Ectomycorrhizal Fungus Paxillus Involutus Converts Organic Matter in Plant Litter Using a Trimmed Brown‐rot Mechanism Involving Fenton Chemistry. Environmental Microbiology 2012, 14, 1477–1487, doi:10.1111/j.1462-2920.2012.02736.x.

Budolfsen, G.; Jensen, M.T.; Heldt-Hansen, H.P.; Stringer, M.A.; Lange, L. Asparaginases and Method of Preparing a Heat-Treated Product 2012. https://patents.google.com/patent/US8124396B2/en

Grell, M.N.; Jensen, A.B.; Olsen, P.B.; Eilenberg, J.; Lange, L. Secretome of Fungus-Infected Aphids Documents High Pathogen Activity and Weak Host Response. Fungal Genetics and Biology 2011, 48, 343–352, doi:10.1016/j.fgb.2010.12.003.

Lange, L.; Wu, W.; Aubert, D.; Landvik, S.; Schnorr, K.M.; Clausen, I.G. Polypeptides Having Cellobiohydrolase I Activity and Polynucleotides Encoding Same 2010. https://patents.google.com/patent/US7785853B2/en

Pedersen, M.; Hollensted, M.; Lange, L.; Andersen, B. Screening for Cellulose and Hemicellulose Degrading Enzymes from the Fungal Genus Ulocladium. International Biodeterioration & Biodegradation 2009, 63, 484–489, doi:10.1016/j.ibiod.2009.01.006.

Wu, W.; Lange, L.; Skovlund, D.A.; Liu, Y. Polypeptides Having Cellobiohydrolase II Activity and Polynucleotides Encoding Same 2008. https://patents.google.com/patent/US7348168B2/en

Schulein, M.; Henriksen, T.; Andersen, L.N.; Lassen, S.F.; Kauppinen, M.S.; Lange, L.; Nielsen, R.I.; Takagi, S.; Ihara, M. Endoglucanases 2008. https://patents.google.com/patent/US20080145912A1/en

Schiøtt, M.; De Fine Licht, H.H.; Lange, L.; Boomsma, J.J. Towards a Molecular Understanding of Symbiont Function: Identification of a Fungal Gene for the Degradation of Xylan in the Fungus Gardens of Leaf-Cutting Ants. BMC Microbiol 2008, 8, 40, doi:10.1186/1471-2180-8-40.

Micheelsen, P.O.; Østergaard, P.R.; Lange, L.; Skjøt, M. High-Level Expression of the Native Barley α-Amylase/Subtilisin Inhibitor in Pichia Pastoris. Journal of Biotechnology 2008, 133, 424–432, doi:10.1016/j.jbiotec.2007.11.012.

Schulein, M.; Henriksen, legal representative T.; Andersen, L.N.; Lassen, S.F.; Kauppinen, M.S.; Lange, L.; Nielsen, R.I.; Takagi, S.; Ihara, M. Endoglucanases 2007. https://patents.google.com/patent/US7226773B2/en

Prasad, A.K.; Kalra, N.; Yadav, Y.; Singh, S.K.; Sharma, S.K.; Patkar, S.; Lange, L.; Olsen, C.E.; Wengel, J.; Parmar, V.S. Selective Biocatalytic Deacylation Studies on Furanose Triesters: A Novel and Efficient Approach towards Bicyclonucleosides. Org. Biomol. Chem. 2007, 5, 3524, doi:10.1039/b711455a.

Prasad, A.K.; Kalra, N.; Yadav, Y.; Kumar, R.; Sharma, S.K.; Patkar, S.; Lange, L.; Wengel, J.; Parmar, V.S. Deacylation Studies on Furanose Triesters Using an Immobilized Lipase: Synthesis of a Key Precursor for Bicyclonucleosides. Chem. Commun. 2007, 2616–2617, doi:10.1039/B618426J.

Hamann, T.; Lange, L. Discovery, Cloning and Heterologous Expression of Secreted Potato Proteins Reveal Erroneous Pre-MRNA Splicing in Aspergillus Oryzae. Journal of Biotechnology 2006, 126, 265–276, doi:10.1016/j.jbiotec.2006.04.026.

Jacobsen, J.; Lydolph, M.; Lange, L. Culture Independent PCR: An Alternative Enzyme Discovery Strategy. Journal of Microbiological Methods 2005, 60, 63–71, doi:10.1016/j.mimet.2004.08.013.

Schülein, M.; Andersen, L.N.; Lassen, S.F.; Kauppinen, M.S.; Lange, L.; Nielsen, R.I.; Ihara, M.; Takagi, S. Endoglucanases 2002. https://patents.google.com/patent/US6387690B1/en

Vincken, J.-P.; Vincken, J.-P.; Borkhardt, B.; Bush, M.; Doeswijk-Voragen, C.; Dopico, B.; Labrador, E.; Lange, L.; McCann, M.; Morvan, C.; et al. Remodelling Pectin Structure In Potato. In Developments in Plant Genetics and Breeding; de Vries, G.E., Metzlaff, K., Eds.; Highlights in European Plant Biotechnology Research and Technology Transfer; Elsevier, 2000; Vol. 6, pp. 245–256. https://www.sciencedirect.com/science/article/pii/S0168797200801292

Dalbøge, H.; Lange, L. Using Molecular Techniques to Identify New Microbial Biocatalysts. Trends in Biotechnology 1998, 16, 265–272, doi:10.1016/S0167-7799(98)01202-5.

Fungi for Saving the World

Lange, L.; Agger, J.W.; Meyer, A.S. Fungal Biotechnology: Unlocking the Full Potential of Fungi for a More Sustainable World. In Grand Challenges in Fungal Biotechnology; Nevalainen, H., Ed.; Grand Challenges in Biology and Biotechnology; Springer International Publishing: Cham, 2020; pp. 3–32 ISBN 978-3-030-29540-0. http://link.springer.com/10.1007/978-3-030-29541-7_1

Lange, L. Fungal Enzymes and Yeasts for Conversion of Plant Biomass to Bioenergy and High-Value Products. Microbiol Spectr 2017, 5, 5.1.13, doi:10.1128/microbiolspec.FUNK-0007-2016.

Lange, L. The Importance of Fungi and Mycology for Addressing Major Global Challenges. IMA Fungus 2014, 5, 463–471, doi:10.5598/imafungus.2014.05.02.10.

Lange, L.; Bech, L.; Busk, P.K.; Grell, M.N.; Huang, Y.; Lange, M.; Linde, T.; Pilgaard, B.; Roth, D.; Tong, X. The Importance of Fungi and of Mycology for a Global Development of the Bioeconomy. IMA Fungus 2012, 3, 87–92, doi:10.5598/imafungus.2012.03.01.09.

Lange, L. The Importance of Fungi for a More Sustainable Future on Our Planet. Fungal Biology Reviews 2010, 24, 90–92, doi:10.1016/j.fbr.2010.12.002.

Larsen, T.O.; Lange, L.; Schnorr, K.; Stender, S.; Frisvad, J.C. Solistatinol, a Novel Phenolic Compactin Analogue from Penicillium Solitum. Tetrahedron Letters 2007, 48, 1261–1264, doi:10.1016/j.tetlet.2006.12.038

Tkacz, J.; Lange, L. Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine; Springer Science+Business Media, 2004; ISBN ISBN 978-1-4613-4694-4. https://link.springer.com/book/10.1007/978-1-4419-8859-1

Lange, L. Microbial Metabolites – an Infinite Source of Novel Chemistry. Pure and Applied Chemistry 1996, 68, 745–748, doi:10.1351/pac199668030745.

Lange, L.; Breinholt, J.; Rasmussen, F.W.; Nielsen, R.I. Microbial Fungicides-the Natural Choice. Pestic. Sci. 1993, 39, 155–160, doi:10.1002/ps.2780390209.

Lange, L. Microbes and Microbial Products in Plant Protection. In Progress in Botany: Stuctural Botany Physiology Genetics Taxonomy Geobotany / Fortschritte der Botanik Struktur Physiologie Genetik Systematik Geobotanik; Behnke, H.-D., Esser, K., Kubitzki, K., Runge, M., Ziegler, H., Eds.; Progress in Botany/Fortschritte der Botanik; Springer: Berlin, Heidelberg, 1992; pp. 252–270 ISBN 978-3-642-77047-0. https://doi.org/10.1007/978-3-642-77047-0_14

Hallman, H.; Lange, L.; Olson, L.; Strömberg, I.; Jonsson, G. Neurochemical and Histochemical Characterization of Neurotoxic Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine on Brain Catecholamine Neurones in the Mouse. Journal of Neurochemistry 1985, 44, 117–127, doi:10.1111/j.1471-4159.1985.tb07120.x

Lange, L. The distribution of macromycetes in Europe. a report of a survey undertaken by the committee for mapping of macromycetes in europe. first half century. Dansk bot. ark. 1974, 30, 7-105 doi:https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL7537002474.

Microbiome research for One Health

NEW Lange, L., Berg, G., Cernava, T. et al. Microbiome ethics, guiding principles for microbiome research, use and knowledge management. Environmental Microbiome 17, 50 (2022). https://doi.org/10.1186/s40793-022-00444-y

Olmo, R.; Wetzels, S.U.; Armanhi, J.S.L.; Arruda, P.; Berg, G.; Cernava, T.; Cotter, P.D.; Araujo, S.C.; de Souza, R.S.C.; Ferrocino, I.; et al. Microbiome Research as an Effective Driver of Success Stories in Agrifood Systems – A Selection of Case Studies. Frontiers in Microbiology 2022, 13, doi: https://doi.org/10.3389/fmicb.2022.834622.

Meisner, A.; Wepner, B.; Kostic, T.; van Overbeek, L.S.; Bunthof, C.J.; de Souza, R.S.C.; Olivares, M.; Sanz, Y.; Lange, L.; Fischer, D.; et al. Calling for a Systems Approach in Microbiome Research and Innovation. Current Opinion in Biotechnology 2022, 73, 171–178, doi:10.1016/j.copbio.2021.08.003.

Coppens, F.; Lange, L.; D’Hondt, K. Aligning Access to Microbiome Data and Privacy Considerations for Better Solutions for Health and Wellbeing of Society and Environments. Annales des Mines 2022, 4. https://www.annales.org/ri/2022/ri-aout-2022/2022-02-09.pdf

Barrett, K.; Lange, L.; Børsting, C.F.; Olijhoek, D.W.; Lund, P.; Meyer, A.S. Changes in the Metagenome-Encoded CAZymes of the Rumen Microbiome Are Linked to Feed-Induced Reductions in Methane Emission From Holstein Cows. Front Microbiol 2022, 13, 855590, doi:10.3389/fmicb.2022.855590.

Berg, G.; Rybakova, D.; Fischer, D.; Cernava, T.; Vergès, M.-C.C.; Charles, T.; Chen, X.; Cocolin, L.; Eversole, K.; Corral, G.H.; et al. Microbiome Definition Re-Visited: Old Concepts and New Challenges. Microbiome 2020, 8, 103, doi:10.1186/s40168-020-00875-0

Dotsenko, G.; Meyer, A.S.; Canibe, N.; Thygesen, A.; Nielsen, M.K.; Lange, L. Enzymatic Production of Wheat and Ryegrass Derived Xylooligosaccharides and Evaluation of Their in Vitro Effect on Pig Gut Microbiota. Biomass Conv. Bioref. 2018, 8, 497–507, doi:10.1007/s13399-017-0298-y.

Grimalt-Alemany, A.; Łężyk, M.; Lange, L.; Skiadas, I.V.; Gavala, H.N. Enrichment of Syngas-Converting Mixed Microbial Consortia for Ethanol Production and Thermodynamics-Based Design of Enrichment Strategies. Biotechnol Biofuels 2018, 11, 198, doi:10.1186/s13068-018-1189-6.

Wilkens, C.; Busk, P.K.; Pilgaard, B.; Zhang, W.-J.; Nielsen, K.L.; Nielsen, P.H.; Lange, L. Diversity of Microbial Carbohydrate-Active Enzymes in Danish Anaerobic Digesters Fed with Wastewater Treatment Sludge. Biotechnology for Biofuels 2017, 10, 158, doi:10.1186/s13068-017-0840-y.

Bioeconomy & Biorefinery Technologies

Lange, L. Christian Patermann and The Bioeconomy: A Testimony on his 80th Anniversary: Important next steps for speeding up and unlocking the full potential of a circular biobased economy. EFB Bioeconomy Journal, 2022. https://doi.org/10.1016/j.bioeco.2022.100037

Barrett Kristian, Zhao Hai, Hao Pengfei, Bacic Antony, Lange Lene, Holck Jesper, Meyer Anne S. Discovery of novel secretome CAZymes from Penicillium sclerotigenum by bioinformatics and explorative proteomics analyses during sweet potato pectin digestion. Frontiers in Bioengineering and Biotechnology, 10, 2022. https://www.frontiersin.org/articles/10.3389/fbioe.2022.950259

Lange, L. Business Models, Including Higher Value Products for the New Circular, Resource-Efficient Biobased Industry. Frontiers in Sustainability 2022, 3. https://doi.org/10.3389/frsus.2022.789435.

Ruiz Sierra, A.; Zika, E.; Lange, L.; Ruiz de Azúa, P.L.; Canalis, A.; Mallorquín Esteban, P.; Paiano, P.; Mengal, P. The Bio-Based Industries Joint Undertaking: A High Impact Initiative That Is Transforming the Bio-Based Industries in Europe. New Biotechnology 2021, 60, 105–112, doi:10.1016/j.nbt.2020.09.003.

Lange, L.; Connor, K.O.; Arason, S.; Bundgård-Jørgensen, U.; Canalis, A.; Carrez, D.; Gallagher, J.; Gøtke, N.; Huyghe, C.; Jarry, B.; et al. Developing a Sustainable and Circular Bio-Based Economy in EU: By Partnering Across Sectors, Upscaling and Using New Knowledge Faster, and For the Benefit of Climate, Environment & Biodiversity, and People & Business. Frontiers in Bioengineering and Biotechnology 2021, 8, doi:https://doi.org/10.3389/fbioe.2020.619066.

Lange, L. Strategies for a Rapid Transition to a Circular, Biobased Society. In Bio#Futures: Foreseeing and Exploring the Bioeconomy; Koukios, E., Sacio-Szymańska, A., Eds.; Springer International Publishing: Cham, 2021; pp. 55–71 ISBN 978-3-030-64969-2. https://doi.org/10.1007/978-3-030-64969-2_4

Lange, L.; Huang, Y. The Potential of Integrated Bio- and Chemical-Engineering—for a More Sustainable World. Green Chemical Engineering 2020, 1, 9–15, doi:10.1016/j.gce.2020.09.002.

Lange, L.; Grandorf Bak, U.; Brandstrup Hansen, S. C.; Gregersen, O.; Harmsen, P.; Nordberg- Karlsson, E.; Meyer, A.S.; Mikkelsen, M.D.; Van Den Broek, L.; Hreggviðsson, G.O. Chapter 1 – Opportunities for seaweed biorefinery, Editor(s): Maria Dolores Torres, Stefan Kraan, Herminia Dominguez, In: Advances in Green and Sustainable Chemistry, Sustainable Seaweed Technologies, Elsevier, 2020, pp 3-31. ISBN 9780128179437. https://doi.org/10.1016/B978-0-12-817943-7.00001-9

Kalafatakis, S.; Zarebska, A.; Lange, L.; Hélix-Nielsen, C.; Skiadas, I.V.; Gavala, H.N. Biofouling Mitigation Approaches during Water Recovery from Fermented Broth via Forward Osmosis. Membranes 2020, 10, 307, doi:10.3390/membranes10110307.

Lucci, G.M.; Henchion, M.M.; Lange, L.; Ledgard, S.F.; Collie, S.R.; Cosgrove, G.P.; Meyer, A.S.; Graichen, F.H.M.; Barth, S.; Lenehan, J.J. Beyond Ruminants: Discussing Opportunities for Alternative Pasture Uses in New Zealand. Journal of NZ Grasslands 2019, 217–222, doi:10.33584/jnzg.2019.81.401.

Lange, L.; Meyer, A.S. Potentials and Possible Safety Issues of Using Biorefinery Products in Food Value Chains. Trends in Food Science & Technology 2019, 84, 7–11, doi:10.1016/j.tifs.2018.08.016.

Bolwig, S.; Tanner, A.N.; Lange, L.; Skött, A.P.; Ahrenfeldt, J.; Andersen, M.; Angelidaki, I.; Bengtsen, P.A.; Clausen, L.R.; Christensen, B.B. Bioøkonomiens maskinrum; 2019; https://backend.orbit.dtu.dk/ws/portalfiles/portal/183320059/108657_sektorudviklingsrapport_bio_net.pdf

Bentil, J.A.; Thygesen, A.; Lange, L.; Mensah, M.; Meyer, A.S. Green Seaweeds (Ulva Fasciata Sp.) as Nitrogen Source for Fungal Cellulase Production. World J Microbiol Biotechnol 2019, 35, 82, doi:10.1007/s11274-019-2658-1.

Lange, L.; Skiadas, I.V.; Gavala, H.N.; Jensen, A.D.; Sárossy, Z.; Thomsen, T.P.; Dam-Johansen, K.; Meyer, A.S.; Angelidaki, I. Sustainable Bioenergy and Biofuels Innovation Challenge. Accelerating the clean energy revolution – perspectives on innovation challenges. DTU Energy report 2018, 63–72, doi:https://orbit.dtu.dk/en/publications/sustainable-bioenergy-and-biofuels-innovation-challenge.

Kalafatakis, S.; Braekevelt, S.; Lymperatou, A.; Zarebska, A.; Hélix-Nielsen, C.; Lange, L.; Skiadas, I.V.; Gavala, H.N. Application of Forward Osmosis Technology in Crude Glycerol Fermentation Biorefinery-Potential and Challenges. Bioprocess Biosyst Eng 2018, 41, 1089–1101, doi:10.1007/s00449-018-1938-8.

Danmarks Tekniske Universitet Accelerating the Clean Energy Revolution: Perspectives on Innovation Challenges; Technical University of Denmark: Roskilde, 2018; ISBN 978-87-93458-57-4. https://orbit.dtu.dk/en/publications/accelerating-the-clean-energy-revolution-perspectives-on-innovati

Kalafatakis, S.; Braekevelt, S.; Carlsen, V.; Lange, L.; Skiadas, I.V.; Gavala, H.N. On a Novel Strategy for Water Recovery and Recirculation in Biorefineries through Application of Forward Osmosis Membranes. Chemical Engineering Journal 2017, 311, 209–216, doi:10.1016/j.cej.2016.11.092.

European Commission. Directorate General for Research and Innovation. Review of the EU Bioeconomy Strategy and Its Action Plan: Expert Group Report.; Publications Office: LU, 2017; https://linkinghub.elsevier.com/retrieve/pii/B9780124095489102544

Dotsenko, G.; Lange, L. Enzyme Enhanced Protein Recovery from Green Biomass Pulp. Waste Biomass Valor 2017, 8, 1257–1264, doi:10.1007/s12649-016-9718-7.

Lange, L.; Lindedam, J. The Fundamentals Of Bioeconomy The Biobased Society 2016. https://stateofgreen.com/en/news/the-fundamentals-of-bioeconomy-the-biobased-society/

Lange, L.; Bryndís Björnsdóttir; Brandt, A.; Hildén, K.; Guðmundur Óli Hreggviðsson; Jacobsen, B.; Jessen, A.; Nordberg Karlsson, E.; Lindedam, J.; Mäkelä, M.; et al. Development of the Nordic Bioeconomy: NCM Reporting: Test Centers for Green Energy Solutions – Biorefineries and Business Needs; TemaNord; Nordic Council of Ministers: Copenhagen, 2015; ISBN 978-92-893-4425-8. https://orbit.dtu.dk/en/publications/development-of-the-nordic-bioeconomy-ncm-reporting-test-centers-f

Lange, L.; Busk, P.K.; Yuhong, H. Use of a Microbial Composition for the Degradation of Keratinaceous Materials 2014. https://patents.google.com/patent/WO2014169920A2/en

Busk, P.; Lange, L. A Novel Method of Providing a Library of N-Mers or Biopolymers 2012. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012101151&recNum=116&docAn=EP2012051099&queryString=(Kinase)%20&maxRec=75503

Budolfsen, G.; Jensen, M.; Heldt-Hansen, H.; Stringer, M.; Lange, L. Method of Preparing a Heat-Treated Product 2008. https://patents.google.com/patent/US20080096260A1/en

Westermann, P.; Jørgensen, B.; Lange, L.; Ahring, B.K.; Christensen, C.H. Maximizing Renewable Hydrogen Production from Biomass in a Bio/Catalytic Refinery. International Journal of Hydrogen Energy 2007, 32, 4135–4141, doi:10.1016/j.ijhydene.2007.06.018.

Lange, L. Tropical Biodiversity, an Industrial Perspective.; Novozymes, 2004. https://studylib.net/doc/9402223/tropical-biodiversity–an-industrial-perspective

Zoosporic Fungi and Viruses

Lange, L.; Barrett, K.; Pilgaard, B.; Gleason, F.; Tsang, A. Enzymes of Early-Diverging, Zoosporic Fungi. Appl Microbiol Biotechnol 2019, 103, 6885–6902, doi:10.1007/s00253-019-09983-w.

Lange, L.; Edén, U.; Olson, L.W. Zoosporogenesis in Pseudoperonospora Cubensis, the Causal Agent of Cucurbit Downy Mildew. Nordic Journal of Botany 1989, 8, 497–504, doi:10.1111/j.1756-1051.1989.tb00527.x.

Lange, L.; Heide, M.; Hobolth, L.; Olson, L.W. Serological Detection of Plasmodiophora Brassicae by Dot Immunobinding and Visualization of the Serological Reaction by Scanning Electron Microscopy. Phytopathology 1989, 79, 1066–1071. doi:https://eurekamag.com/research/007/784/007784143.php

Roongruangsree, U.-T.; Olson, L.W.; Lange, L. The Seed-Borne Inoculum of Peronospora Manshurica, Causal Agent of Soybean Downy Mildew. Journal of Phytopathology 1988, 123, 233–243, doi:10.1111/j.1439-0434.1988.tb04473.x.

Roongruangsree, U.-T.; Kjerulf-Jensen, C.; Olson, L.W.; Lange, L. Viability Tests for Thick Walled Fungal Spores (Ex: Oospores of Peronospora Manshurica). Journal of Phytopathology 1988, 123, 244–252, doi:10.1111/j.1439-0434.1988.tb04474.x.

Heide, M.; Lange, L. Detection of Potato Leaf Roll Virus and Potato Viruses M, S, X and Y by Dot Immunobinding on Plain Paper. Potato Res 1988, 31, 367–373, doi:10.1007/BF02357870.

Sewall, T.; Olson, L.; Lange, L.; Pommerville, J. The Effect of Monensin on Gametogenesis and Zoosporogenesis in the Aquatic Fungus,Allomyces Macrogynus. Protoplasma 1986, 133, 129–139, doi:10.1007/BF01304628.

Lange, L. Practical Application of New Developments in Test Prodecures for the Detection of Viruses in Seed. Developments in applied biology 1986. https://agris.fao.org/agris-search/search.do?recordID=US201301745986

Lange, L.; Heide, M. Dot Immuno Binding (DIB) for Detection of Virus in Seed. Canadian Journal of Plant Pathology 1986, 8, 373–379, doi:10.1080/07060668609501772.

Lange, L.; Olson, L.W.; Safeeulla, K.M. Pearl Millet Downy Mildew (Sclerospora Graminicola): Zoosporogenesis. Protoplasma 1984, 119, 178–187, doi:10.1007/BF01288872.

Cerenius, L.; Olson, L.W.; Lange, L.; Söderhäll, K. The Secondary Zoospore of Aphanomyces Astaci and A. Laevis (Oomycetes, Saprolegniales). Nordic Journal of Botany 1984, 4, 696–706, doi:10.1111/j.1756-1051.1984.tb01995.x.

Olson, L.W.; Lange, L. The Gamma Body: A Vesicle Generating Structure. Nordic Journal of Botany 1983, 3, 673–680, doi:10.1111/j.1756-1051.1983.tb01478.x.

Olson, L.W.; Lange, L. Abnormal Spore Cleavage: Abnormal Spores of Allomyces Macrogynus. Nordic Journal of Botany 1983, 3, 657–664, doi:10.1111/j.1756-1051.1983.tb01476.x.

Lange, L. The Fungal Zoospores – Its Structure and Biosignificance. Zoosporic Plant Pathogen 1983, 1–42. https://cir.nii.ac.jp/crid/1572543024329737728

Lange, L.; Tien, P.; Begtrup, J. The Potential of ELISA and ISEM in Seed Health Testing, [Viruses]. Seed Science and Technology (Netherlands) 1983. https://agris.fao.org/agris-search/search.do?recordID=XE8482191

Lange, L.; Olson, L.W. Germination and Parasitation of the Resting Sporangia of Synchytrium Endobioticum. Protoplasma 1981, 106, 69–82, doi:10.1007/BF02115962.

Lange, L.; Olson, L.W. Development of the Resting Sporangia of Synchytrium Endobioticum, the Causal Agent of Potato Wart Disease. Protoplasma 1981, 106, 83–95, doi:10.1007/BF02115963.

Lange, L.; Olson, L.W. Transfer of the Physodermataceae from the Chytridiales to the Blastocladiales. Transactions of the British Mycological Society 1980, 74, 449–457, doi:10.1016/S0007-1536(80)80043-X.

Lange, L.; Olson, L.W. Germination of the Resting Sporangia of Physoderma Maydis, the Causal Agent of Physoderma Disease of Maize. Protoplasma 1980, 102, 323–342, doi:10.1007/BF01279596.

Lange, L.; Olsen, L. Uniflagellate Phycomycete Zoospore; Dansk botanisk forening, 1979; ISBN 87-7420-021-6. https://scholar.google.com/scholar_lookup?title=uniflagellate+phycomycete+zoospore&author=Lange%2C+Lene.&publication_year=1979

Lene Lange, L.; Olson, L.W. The Zoospore of Olpidium Radicale. Transactions of the British Mycological Society 1978, 71, 43–55, doi:10.1016/S0007-1536(78)80006-0.

Lange, L.; Olson, L.W. The Zoospore of Synchytrium Endobioticum. Can. J. Bot. 1978, 56, 1229–1239, doi:10.1139/b78-137.

Lange, L. Synchytrium Endobioticum and Potato Virus X. Journal of Phytopathology 1978, 92, 132–142, doi:10.1111/j.1439-0434.1978.tb03594.x.

Sparrow, F.K.; Lange, L. Some Bog Chytrids. Can. J. Bot. 1977, 55, 1879–1890, doi:10.1139/b77-216.

Lange, L.; Olson, L.W. The Zoospore of Phlyctochytrium Aestuarii. Protoplasma 1977, 93, 27–43, doi:10.1007/BF01276280.

Lange, L.; Insunza, V. Root-Inhabiting Olpidium Species: The O. Radicale Complex. Transactions of the British Mycological Society 1977, 69, 377–384, doi:10.1016/S0007-1536(77)80074-0.

Lange, L.; Olson, L.W. The Zoospore of Olpidium Brassicae. Protoplasma 1976, 90, 33–45, doi:10.1007/BF01276478.

Lange, L.; Olson, L.W. The Flagellar Apparatus and Striated Rhizoplast of the Zoospore of Olpidium Brassicae. Protoplasma 1976, 89, 339–351, doi:10.1007/BF01275750.